BimEL-I188E

General Information


DRACP ID  DRACP03044

Peptide Name   BimEL-I188E

Sequence  PQMVILQLLRFEFRLVWRRH

Sequence Length  20

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-2/Bcl-xL

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03044

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C124H197N37O25S

Absent amino acids  ACDGKNSTY

Common amino acids  LR

Mass  297730

Pl  12.5

Basic residues  5

Acidic residues  1

Hydrophobic residues  10

Net charge  4

Boman Index  -3891

Hydrophobicity  7

Aliphatic Index  126.5

Half Life 
  Mammalian: >20 hour
  Yeast: >20 hour
  E.coli: ?

Extinction Coefficient cystines  5500

Absorbance 280nm  289.47

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30860026

Title  Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2

Doi 10.7554/eLife.37689

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.