This work is licensed under a Creative Commons Attribution 4.0 International License.
BimEL-CST-2A (R186A-R190A)
General Information
DRACP ID DRACP03046
Peptide Name BimEL-CST-2A (R186A-R190A)
Sequence PQMVILQLLAFIFALVWRRH
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H187N31O23S
Absent amino acids CDEGKNSTY
Common amino acids L
Mass 279115
Pl 12.5
Basic residues 3
Acidic residues 0
Hydrophobic residues 13
Net charge 3
Boman Index 628
Hydrophobicity 110
Aliphatic Index 156
Half Life
Mammalian: >20 hour
Yeast: >20 hour
E.coli: ?
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30860026
Title Bim escapes displacement by BH3-mimetic anti-cancer drugs by double-bolt locking both Bcl-XL and Bcl-2
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.