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Bim SM-5
General Information
DRACP ID DRACP03051
Peptide Name Bim SM-5
Sequence IAQELRRIGDEF
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | 26% Killing= 50 μM | MTT assay | 48 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 21% Killing= 50 μM | MTT assay | 48 h | 1 |
| U-937 | Adult acute monocytic leukemi; Acute monoblastic/monocytic leukemia | Leukemia | 40% Killing= 50 μM | MTT assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C63H103N19O20
Absent amino acids CHKMNPSTVWY
Common amino acids EIR
Mass 164302
Pl 4.43
Basic residues 2
Acidic residues 3
Hydrophobic residues 5
Net charge -1
Boman Index -3723
Hydrophobicity -50
Aliphatic Index 105.83
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain
Doi 10.1016/j.cclet.2017.03.010
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.