Bim SM-7

General Information


DRACP ID  DRACP03053

Peptide Name   Bim SM-7

Sequence  IAQELRRIGDEF

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bac-2 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-2

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03053

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  mPEG, CH3(OCH2CH2)4OCH2CO

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C63H103N19O20

Absent amino acids  CHKMNPSTVWY

Common amino acids  EIR

Mass  164302

Pl  4.43

Basic residues  2

Acidic residues  3

Hydrophobic residues  5

Net charge  -1

Boman Index  -3723

Hydrophobicity  -50

Aliphatic Index  105.83

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Discovery of novel inhibitors of anti-apoptotic Bcl-2proteins derived from Bim BH3 domain

Doi 10.1016/j.cclet.2017.03.010

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.