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Bim BH3 (I155R, E158A)
General Information
DRACP ID DRACP03056
Peptide Name Bim BH3 (I155R, E158A)
Sequence EIWIAQELRRRGDAFNAYYAR
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-2/Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C117H176N36O32
Absent amino acids CHKMPSTV
Common amino acids AR
Mass 295583
Pl 9.17
Basic residues 4
Acidic residues 3
Hydrophobic residues 9
Net charge 1
Boman Index -6623
Hydrophobicity -79.05
Aliphatic Index 74.76
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 8480
Absorbance 280nm 424
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26136077
Title Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.