Bim BH3 (E158S)

General Information


DRACP ID  DRACP03059

Peptide Name   Bim BH3 (E158S)

Sequence  EIWIAQELRRIGDSFNAYYAR

Sequence Length  21

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bcl-xL/Bac-2 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bcl-2/Bcl-xL

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03059

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C117H175N33O33

Absent amino acids  CHKMPTV

Common amino acids  AIR

Mass  292880

Pl  6.57

Basic residues  3

Acidic residues  3

Hydrophobic residues  9

Net charge  0

Boman Index  -5160

Hydrophobicity  -48.57

Aliphatic Index  88.57

Half Life 
  Mammalian: 1 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  8480

Absorbance 280nm  424

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26136077

Title  Conversion of cell-survival activity of Akt into apoptotic death of cancer cells by two mutations on the BIM BH3 domain

Doi 10.1038/cddis.2015.118

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.