This work is licensed under a Creative Commons Attribution 4.0 International License.
Bad-BH3
General Information
DRACP ID DRACP03060
Peptide Name Bad-BH3
Sequence LWAAQRYGRELRRMSDEFEGSFKGL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C133H204N40O38S
Absent amino acids CHINPTV
Common amino acids R
Mass 343164
Pl 9.29
Basic residues 5
Acidic residues 4
Hydrophobic residues 8
Net charge 1
Boman Index -7502
Hydrophobicity -87.6
Aliphatic Index 54.8
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 291.25
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25451027
Title Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.