This work is licensed under a Creative Commons Attribution 4.0 International License.
A12
General Information
DRACP ID DRACP03064
Peptide Name A12
Sequence RPEIWMGQGLRRLGDEINAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Mcl-1 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Mcl-1
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification 5/6-Fluorescein amidite
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C122H190N38O34S
Absent amino acids CFHKSTV
Common amino acids R
Mass 315774
Pl 9.17
Basic residues 4
Acidic residues 3
Hydrophobic residues 7
Net charge 1
Boman Index -6368
Hydrophobicity -85.65
Aliphatic Index 76.52
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 8480
Absorbance 280nm 385.45
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25052212
Title Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.