G9

General Information


DRACP ID  DRACP03066

Peptide Name   G9

Sequence  RPEIWLGQHLQRLGDEINAYYAR

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Mcl-1 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Mcl-1

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03066

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  5/6-Fluorescein amidite

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C126H192N38O35

Absent amino acids  CFKMSTV

Common amino acids  LR

Mass  319175

Pl  7.54

Basic residues  4

Acidic residues  3

Hydrophobic residues  8

Net charge  1

Boman Index  -5733

Hydrophobicity  -85.22

Aliphatic Index  93.48

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  8480

Absorbance 280nm  385.45

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25052212

Title  Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

Doi 10.1021/cb500340w

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.