This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim-A2eT
General Information
DRACP ID DRACP03069
Peptide Name Bim-A2eT
Sequence RPEIWITQELRRIGDEFNAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Mcl-1 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Mcl-1
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification 5/6-Fluorescein amidite
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C131H198N38O37
Absent amino acids CHKMSV
Common amino acids R
Mass 328983
Pl 6.64
Basic residues 4
Acidic residues 4
Hydrophobic residues 8
Net charge 0
Boman Index -7431
Hydrophobicity -93.48
Aliphatic Index 76.52
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 8480
Absorbance 280nm 385.45
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25052212
Title Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.