Bim-FD2

General Information


DRACP ID  DRACP03075

Peptide Name   Bim-FD2

Sequence  RPEIWMAQVLRRFGDLLNAYYAR

Sequence Length  23

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Bfl-1 inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Bfl-1

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03075

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C130H200N38O32S

Absent amino acids  CHKST

Common amino acids  R

Mass  323191

Pl  10.11

Basic residues  4

Acidic residues  2

Hydrophobic residues  10

Net charge  2

Boman Index  -4992

Hydrophobicity  -31.74

Aliphatic Index  93.48

Half Life 
  Mammalian: 1 hour
  Yeast: 2 min
  E.coli: 2 min

Extinction Coefficient cystines  8480

Absorbance 280nm  385.45

Polar residues  4

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23363053

Title  Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening

Doi 10.1021/cb300679a

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.