This work is licensed under a Creative Commons Attribution 4.0 International License.
Bim-FD2
General Information
DRACP ID DRACP03075
Peptide Name Bim-FD2
Sequence RPEIWMAQVLRRFGDLLNAYYAR
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Bfl-1 inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Bfl-1
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C130H200N38O32S
Absent amino acids CHKST
Common amino acids R
Mass 323191
Pl 10.11
Basic residues 4
Acidic residues 2
Hydrophobic residues 10
Net charge 2
Boman Index -4992
Hydrophobicity -31.74
Aliphatic Index 93.48
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 8480
Absorbance 280nm 385.45
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23363053
Title Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.