This work is licensed under a Creative Commons Attribution 4.0 International License.
LIB11
General Information
DRACP ID DRACP03087
Peptide Name LIB11
Sequence MRPEIWIAQELRRNGDEVNAYYARRVZ
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce apoptosis Mcl-1/Bcl-xL inhibitors BH3 peptides and mimetics
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Mcl-1/Bcl-xL
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C140H219N45O39S
Absent amino acids CFHKST
Common amino acids R
Mass 365255
Pl 9.17
Basic residues 5
Acidic residues 4
Hydrophobic residues 9
Net charge 1
Boman Index -8896
Hydrophobicity -88.89
Aliphatic Index 75.93
Half Life
/
Extinction Coefficient cystines 8480
Absorbance 280nm 326.15
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 20363230
Title Determinants of BH3 binding specificity for Mcl-1 versus Bcl-Xl
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.