LIB39

General Information


DRACP ID  DRACP03115

Peptide Name   LIB39

Sequence  MRPEIWIAQEIRRDGDENNAYYARRVZ

Sequence Length  27

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Induce apoptosis Mcl-1/Bcl-xL inhibitors BH3 peptides and mimetics



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Mcl-1/Bcl-xL

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C139H215N45O41S

Absent amino acids  CFHKLST

Common amino acids  R

Mass  366851

Pl  6.67

Basic residues  5

Acidic residues  5

Hydrophobic residues  8

Net charge  0

Boman Index  -10172

Hydrophobicity  -114.81

Aliphatic Index  65.19

Half Life 
  /

Extinction Coefficient cystines  8480

Absorbance 280nm  326.15

Polar residues  5

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 20363230

Title  Determinants of BH3 binding specificity for Mcl-1 versus Bcl-Xl

Doi 10.1016/j.jmb.2010.03.058

Year  2010

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.