This work is licensed under a Creative Commons Attribution 4.0 International License.
Tyrocidine A, TA
General Information
DRACP ID DRACP03456
Peptide Name Tyrocidine A, TA
Sequence fPFfNQYVXL
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antiparasitic; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral Mix
Physicochemical Information
Formula C43H55N9O8
Absent amino acids ACDEGHIKMRSTW
Common amino acids FLNPQVYX
Mass 109667
Pl 6.09
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index -38
Hydrophobicity 9
Aliphatic Index 68
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 165.56
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29140694
Title Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity
Doi Not available
Year 2017
Literature 2
Pubmed ID 30301848
Title The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S
Doi Not available
Year 2018
Literature 3
Pubmed ID 27328781
Title Antifungal membranolytic activity of the tyrocidines against filamentous plant fungi
Doi Not available
Year 2016
Literature 4
Pubmed ID 17462586
Title Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis
Doi Not available
Year 2007
Literature 5
Pubmed ID 24752256
Title Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms
Doi Not available
Year 2014
Literature 6
Pubmed ID 19586775
Title Anti-listerial activity and structure-activity relationships of the six major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus
Doi Not available
Year 2009
Literature 7
Pubmed ID 17728134
Title Development of Tyrocidine A analogues with improved antibacteri
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 3316
This work is licensed under a Creative Commons Attribution 4.0 International License.