Tyrocidine A, TA

General Information


DRACP ID  DRACP03456

Peptide Name   Tyrocidine A, TA

Sequence  fPFfNQYVXL

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Native peptide

Classification

  

Active ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antiparasitic; Antifungal



Structure Information


PDB ID  4M6E 

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  Mix



Physicochemical Information


Formula  C43H55N9O8

Absent amino acids  ACDEGHIKMRSTW

Common amino acids  FLNPQVYX

Mass  109667

Pl  6.09

Basic residues  0

Acidic residues  0

Hydrophobic residues  3

Net charge  0

Boman Index  -38

Hydrophobicity  9

Aliphatic Index  68

Half Life 
  /

Extinction Coefficient cystines  1490

Absorbance 280nm  165.56

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 29140694

Title  Tyrocidine A Analogues Bearing the Planar d-Phe-2-Abz Turn Motif: How Conformation Impacts Bioactivity

Doi Not available

Year  2017

Literature 2

Pubmed ID 30301848

Title  The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S

Doi Not available

Year  2018

Literature 3

Pubmed ID 27328781

Title  Antifungal membranolytic activity of the tyrocidines against filamentous plant fungi

Doi Not available

Year  2016

Literature 4

Pubmed ID 17462586

Title  Inhibition of malaria parasite blood stages by tyrocidines, membrane-active cyclic peptide antibiotics from Bacillus brevis

Doi Not available

Year  2007

Literature 5

Pubmed ID 24752256

Title  Synergistic activity of the tyrocidines, antimicrobial cyclodecapeptides from Bacillus aneurinolyticus, with amphotericin B and caspofungin against Candida albicans biofilms

Doi Not available

Year  2014

Literature 6

Pubmed ID 19586775

Title  Anti-listerial activity and structure-activity relationships of the six major tyrocidines, cyclic decapeptides from Bacillus aneurinolyticus

Doi Not available

Year  2009

Literature 7

Pubmed ID 17728134

Title  Development of Tyrocidine A analogues with improved antibacteri

Doi 

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  3316

DRACP is developed by Dr.Zheng's team.