This work is licensed under a Creative Commons Attribution 4.0 International License.
Protegrin-3
General Information
DRACP ID DRACP03477
Peptide Name Protegrin-3
Sequence RGGGLCYCRRRFCVCVGR
Sequence Length 18
UniProt ID P32196
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C84H141N33O20S4
Absent amino acids ADEHIKMNPQSTW
Common amino acids R
Mass 236490
Pl 9.72
Basic residues 5
Acidic residues 0
Hydrophobic residues 4
Net charge 5
Boman Index -4988
Hydrophobicity -2.22
Aliphatic Index 53.89
Half Life
Mammalian: 1.4 hour
Yeast: 3 min
E.coli: >10 hour
Extinction Coefficient cystines 1740
Absorbance 280nm 102.35
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25818457
Title Characterization of cell selectivity, physiological stability and endotoxin neutralization capabilities of ?-helix-based peptide amphiphiles
Doi Not available
Year 2015
Literature 2
Pubmed ID 15629531
Title Protegrin structure-activity relationships: using homology models of Synthetic peptide sequences to determine structural characteristics important for activity
Doi Not available
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 4756
This work is licensed under a Creative Commons Attribution 4.0 International License.