This work is licensed under a Creative Commons Attribution 4.0 International License.
Protegrin 4, PG4
General Information
DRACP ID DRACP03478
Peptide Name Protegrin 4, PG4
Sequence RGGRLCYCRGWICFCVGR
Sequence Length 18
UniProt ID P49933
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C90H141N31O20S4
Absent amino acids ADEHKMNPQST
Common amino acids CGR
Mass 240896
Pl 9.08
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -3175
Hydrophobicity 19.44
Aliphatic Index 59.44
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 7240
Absorbance 280nm 425.88
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30714272
Title Mammalian antimicrobial peptide protegrin-4 self assembles and forms amyloid-like aggregates: Assessment of its functional relevance
Doi Not available
Year 2019
Literature 2
Pubmed ID 15629531
Title Protegrin structure-activity relationships: using homology models of Synthetic peptide sequences to determine structural characteristics important for activity
Doi Not available
Year 2005
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 4757
This work is licensed under a Creative Commons Attribution 4.0 International License.