This work is licensed under a Creative Commons Attribution 4.0 International License.
Kalata B2
General Information
DRACP ID DRACP03483
Peptide Name Kalata B2
Sequence GLPVCGETCFGGTCNTPGCSCTWPICTRD
Sequence Length 29
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H188N34O41S6
Absent amino acids AHKMQY
Common amino acids C
Mass 347902
Pl 4.18
Basic residues 1
Acidic residues 2
Hydrophobic residues 5
Net charge -1
Boman Index -2177
Hydrophobicity 11.38
Aliphatic Index 36.9
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5875
Absorbance 280nm 209.82
Polar residues 18
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25099014
Title Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting
Doi Not available
Year 2014
Literature 2
Pubmed ID 18618891
Title The anthelmintic activity of the cyclotides: natural variants with enhanced activity
Doi Not available
Year 2008
Literature 3
Pubmed ID 28669767
Title Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
Doi Not available
Year 2017
Literature 4
Pubmed ID 15654741
Title Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do M枚bius strips exist in nature?
Doi Not available
Year 2005
Literature 5
Pubmed ID 20564013
Title Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis
Doi Not available
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 5236
This work is licensed under a Creative Commons Attribution 4.0 International License.