This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 (15-32)[E1G], GF-17
General Information
DRACP ID DRACP03512
Peptide Name LL-37 (15-32)[E1G], GF-17
Sequence GFKRIVQRIKDFLRNLV
Sequence Length 17
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C97H164N30O22
Absent amino acids ACEHMPSTWY
Common amino acids R
Mass 238813
Pl 12.24
Basic residues 5
Acidic residues 1
Hydrophobic residues 8
Net charge 4
Boman Index -4210
Hydrophobicity -9.41
Aliphatic Index 125.88
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34959645
Title Structure and Activity of a Selective Antibiofilm Peptide SK-24 Derived from the NMR Structure of Human Cathelicidin LL-37
Doi Not available
Year 2021
Literature 2
Pubmed ID 32252021
Title Engineered Human Cathelicidin Antimicrobial Peptides Inhibit Ebola Virus Infection
Doi Not available
Year 2021
Literature 3
Pubmed ID 30800727
Title Amino Acid Composition Determines Peptide Activity Spectrum and Hot-Spot-Based Design of Merecidin
Doi Not available
Year 2018
Literature 4
Pubmed ID 19581460
Title Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37
Doi Not available
Year 2009
Literature 5
Pubmed ID 28450045
Title Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes
Doi Not available
Year 2017
Literature 6
Pubmed ID 22083479
Title Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37
Doi Not available
Year 2012
Literature 7
Pubmed ID 20086159
Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database
Doi N
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6070
This work is licensed under a Creative Commons Attribution 4.0 International License.