Cyclo(Pro-Phe), Diketopiperazine (PF)

General Information


DRACP ID  DRACP03534

Peptide Name   Cyclo(Pro-Phe), Diketopiperazine (PF)

Sequence  PF

Sequence Length  2

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Native peptide

Classification

  

Active ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP03534

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C14H18N2O3

Absent amino acids  ACDEGHIKLMNQRSTVWY

Common amino acids  FP

Mass  28032

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  1

Net charge  0

Boman Index  298

Hydrophobicity  60

Aliphatic Index  0

Half Life 
  Mammalian:
  Yeast:
  E.coli:

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25821788

Title  Cytotoxicity of cyclodipeptides from Pseudomonas aeruginosa PAO1 leads to apoptosis in human cancer cell lines

Doi Not available

Year  2015

Literature 2

Pubmed ID 33924262

Title  Antimicrobial and Antibiofilm Activities of the Fungal Metabolites Isolated from the Marine Endophytes Epicoccum nigrum M13 and Alternaria alternata 13A

Doi Not available

Year  2021

Literature 3

Pubmed ID 29351264

Title  Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia Solanacearum

Doi Not available

Year  2018

Literature 4

Pubmed ID 30270742

Title  Chemical constituents from the deep sea-derived Streptomyces xiamenensis MCCC 1A01570 and their effects on RXR伪 transcriptional regulation

Doi Not available

Year  2020

Literature 5

Pubmed ID 24622848

Title  In vitro antibacterial screening of six proline-based cyclic dipeptides in combination with ?-lactam antibiotics against medically important bacteria

Doi Not available

Year  2014

Literature 6

Pubmed ID 23065379

Title  Isolation of proline-based cyclic dipeptides from Bacillus sp N strain associated with rhabditid entomopathogenic nematode and its antimicrobial properties

Doi Not

Year 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  6742

DRACP is developed by Dr.Zheng's team.