This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 KR-12-a4
General Information
DRACP ID DRACP03538
Peptide Name LL-37 KR-12-a4
Sequence KRIVKLIKKWLR
Sequence Length 12
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H137N23O13
Absent amino acids ACDEFGHMNPQSTY
Common amino acids K
Mass 177746
Pl 12.56
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -2599
Hydrophobicity -39.17
Aliphatic Index 154.17
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 35288606
Title A novel hybrid peptide composed of LfcinB6 and KR-12-a4 with enhanced antimicrobial, anti-inflammatory and anti-biofilm activities
Doi Not available
Year 2022
Literature 2
Pubmed ID 24105706
Title Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity
Doi Not available
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6829
This work is licensed under a Creative Commons Attribution 4.0 International License.