This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 KR-12-a5
General Information
DRACP ID DRACP03539
Peptide Name LL-37 KR-12-a5
Sequence KRIVKLILKWLR
Sequence Length 12
UniProt ID P49913
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C76H136N22O13
Absent amino acids ACDEFGHMNPQSTY
Common amino acids KL
Mass 176245
Pl 12.55
Basic residues 5
Acidic residues 0
Hydrophobic residues 7
Net charge 5
Boman Index -1552
Hydrophobicity 25
Aliphatic Index 186.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28525841
Title LL-37-derived short antimicrobial peptide KR-12-a5 and its d-amino acid substituted analogs with cell selectivity, anti-biofilm activity, synergistic effect with conventional antibiotics, and anti-inflammatory activity
Doi Not available
Year 2017
Literature 2
Pubmed ID 29022391
Title KR-12-a5 is a non-cytotoxic agent with potent antimicrobial effects against oral pathogens
Doi Not available
Year 2017
Literature 3
Pubmed ID 24105706
Title Short KR-12 analogs designed from human cathelicidin LL-37 possessing both antimicrobial and antiendotoxic activities without mammalian cell toxicity
Doi Not available
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 6830
This work is licensed under a Creative Commons Attribution 4.0 International License.