This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclo(Trp-Leu), Diketopiperazine (WL)
General Information
DRACP ID DRACP03547
Peptide Name Cyclo(Trp-Leu), Diketopiperazine (WL)
Sequence WL
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C17H23N3O3
Absent amino acids ACDEFGHIKMNPQRSTVY
Common amino acids LW
Mass 33541
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 725
Hydrophobicity 145
Aliphatic Index 195
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 5500
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32806659
Title C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities
Doi Not available
Year 2020
Literature 2
Pubmed ID 22617493
Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Doi Not available
Year 2012
Literature 3
Pubmed ID 24120705
Title Purification, structural elucidation and bioactivity of tryptophan containing diketopiperazines, from Comamonas testosteroni associated with a rhabditid entomopathogenic nematode against major human-pathogenic bacteria
Doi Not available
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7134
This work is licensed under a Creative Commons Attribution 4.0 International License.