This work is licensed under a Creative Commons Attribution 4.0 International License.
Oncocin
General Information
DRACP ID DRACP03555
Peptide Name Oncocin
Sequence VDKPPYLPRPRPPRRIYNR
Sequence Length 19
UniProt ID A0A2R7WNA0
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C109H176N36O25
Absent amino acids ACEFGHMQSTW
Common amino acids P
Mass 271203
Pl 11.95
Basic residues 6
Acidic residues 1
Hydrophobic residues 3
Net charge 5
Boman Index -8191
Hydrophobicity -174.21
Aliphatic Index 56.32
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 2980
Absorbance 280nm 165.56
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Design and Characterization of a Novel Hybrid Antimicrobial Peptide OM19R Based on Oncocin and MDAP-2
Doi Not available
Year 2019
Literature 2
Pubmed ID 26334348
Title Optimization of oncocin for antibacterial activity using a SPOT synthesis approach: extending the pathogen spectrum to Staphylococcus aureus
Doi Not available
Year 2016
Literature 3
Pubmed ID 31105969
Title Systematic Mutagenesis of Oncocin Reveals Enhanced Activity and Insights into the Mechanisms of Antimicrobial Activity
Doi Not available
Year 2018
Literature 4
Pubmed ID 21185160
Title Bactericidal oncocin derivatives with superior serum stabilities
Doi Not available
Year 2011
Literature 5
Pubmed ID 25730460
Title Hydrophilic/hydrophobic characters of antimicrobial peptides derived from animals and their effects on multidrug resistant clinical isolates
Doi Not available
Year 2015
Literature 6
Pubmed ID 20565063
Title Oncocin (VDKPPYLPRPRPPRRIYNR-NH2): a novel antibacterial peptide optimized against gram-negative human pathogens
Doi Not available
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7484
This work is licensed under a Creative Commons Attribution 4.0 International License.