This work is licensed under a Creative Commons Attribution 4.0 International License.
Leucrocin I RT2
General Information
DRACP ID DRACP03560
Peptide Name Leucrocin I RT2
Sequence NGVQPKYRWWRWWRRWW
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C126H164N38O21
Absent amino acids ACDEFHILMST
Common amino acids W
Mass 283248
Pl 12.51
Basic residues 5
Acidic residues 0
Hydrophobic residues 7
Net charge 5
Boman Index -5859
Hydrophobicity -196.47
Aliphatic Index 17.06
Half Life
Mammalian: 3.5 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 34490
Absorbance 280nm 2155.63
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30031283
Title KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells
Doi Not available
Year 2018
Literature 2
Pubmed ID 27129462
Title Cationic Antimicrobial Peptides Derived from Crocodylus siamensis Leukocyte Extract, Revealing Anticancer Activity and Apoptotic Induction on Human Cervical Cancer Cells
Doi Not available
Year 2016
Literature 3
Pubmed ID 25767037
Title Cationic amphipathic peptides KT2 and RT2 are taken up into bacterial cells and kill planktonic and biofilm bacteria
Doi Not available
Year 2015
Literature 4
Pubmed ID 23831136
Title Improving the antibacterial activity and selectivity of an ultra short peptide by hydrophobic and hydrophilic amino acid stretches
Doi Not available
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 7582
This work is licensed under a Creative Commons Attribution 4.0 International License.