This work is licensed under a Creative Commons Attribution 4.0 International License.
[R4W4]
General Information
DRACP ID DRACP03596
Peptide Name [R4W4]
Sequence RRRRWWWW
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C68H90N24O9
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids RW
Mass 151264
Pl 12.98
Basic residues 4
Acidic residues 0
Hydrophobic residues 4
Net charge 4
Boman Index -5036
Hydrophobicity -270
Aliphatic Index 0
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 22000
Absorbance 280nm 3142.86
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 36442155
Title Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics
Doi Not available
Year 2022
Literature 2
Pubmed ID 30360400
Title Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents
Doi Not available
Year 2018
Literature 3
Pubmed ID 28594345
Title Synthesis and Evaluation of Antimicrobial Activity of [R4W4K]-Levofloxacin and [R4W4K]-Levofloxacin-Q Conjugates
Doi Not available
Year 2017
Literature 4
Pubmed ID 25157458
Title Antibacterial activities of amphiphilic cyclic cell-penetrating peptides against multidrug-resistant pathogens
Doi Not available
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 8109
This work is licensed under a Creative Commons Attribution 4.0 International License.