OsDef2 (16-37)

General Information


DRACP ID  DRACP03610

Peptide Name   OsDef2 (16-37)

Sequence  KGIRGYKGGYCKGAFKQTCKCY

Sequence Length  22

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C109H171N31O28S3

Absent amino acids  DEHLMNPSVW

Common amino acids  GK

Mass  283469

Pl  10.03

Basic residues  6

Acidic residues  0

Hydrophobic residues  3

Net charge  6

Boman Index  -3295

Hydrophobicity  -79.55

Aliphatic Index  22.27

Half Life 
  Mammalian: 3.5 hour
  Yeast: 10 min
  E.coli: >10 hour

Extinction Coefficient cystines  4595

Absorbance 280nm  218.81

Polar residues  12

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 34866278

Title  Antifungal activity and mode of action of Synthetic peptide peptides derived from the tick OsDef2 defensin

Doi Not available

Year  2022

Literature 2

Pubmed ID 31713951

Title  Antimicrobial Function of Short Amidated Peptide Fragments From the Tick-Derived OsDef2 Defensin

Doi Not available

Year  2019

Literature 3

Pubmed ID 26215047

Title  Investigation into the mechanism of action of the antimicrobial peptides Os and Os-C derived from a tick defensin

Doi Not available

Year  2015

Literature 4

Pubmed ID 23553969

Title  Structural and functional characterization of peptides derived from the carboxy-terminal region of a defensin from the tick Ornithodoros savignyi

Doi Not available

Year  2013

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  8286

DRACP is developed by Dr.Zheng's team.