This work is licensed under a Creative Commons Attribution 4.0 International License.
A3 Single chain (1-20)AMD
General Information
DRACP ID DRACP03616
Peptide Name A3 Single chain (1-20)AMD
Sequence XRPDKPRPYLPRPRPPRPVR
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C106H174N38O22
Absent amino acids ACEFGHIMNQSTW
Common amino acids P
Mass 278182
Pl 12.51
Basic residues 7
Acidic residues 1
Hydrophobic residues 2
Net charge 6
Boman Index -9497
Hydrophobicity -202.5
Aliphatic Index 34
Half Life
/
Extinction Coefficient cystines 1490
Absorbance 280nm 78.42
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26384569
Title Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane
Doi Not available
Year 2015
Literature 2
Pubmed ID 30155456
Title Synergy Between Proline-Rich Antimicrobial Peptides and Small Molecule Antibiotics Against Selected Gram-Negative Pathogens in vitro and in vivo
Doi Not available
Year 2018
Literature 3
Pubmed ID 30186829
Title Advantage of a Narrow Spectrum Host Defense (Antimicrobial) Peptide Over a Broad Spectrum Analog in Preclinical Drug Development
Doi Not available
Year 2018
Literature 4
Pubmed ID Not available
Title C-terminal modifications broaden the activity of the proline-rich antimicrobial peptide, Chex1-Arg20
Doi Not available
Year 2015
Literature 5
Pubmed ID 18721837
Title Scope and limitations of the designer proline-rich antibacterial peptide dimer, A3-APO, alone or in synergy with conventional antibiotics
Doi Not available
Year 2008
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 8551
This work is licensed under a Creative Commons Attribution 4.0 International License.