This work is licensed under a Creative Commons Attribution 4.0 International License.
Brevinin 2R
General Information
DRACP ID DRACP03812
Peptide Name Brevinin 2R
Sequence KLKNFAKGVAQSLLNKASCKLSGQC
Sequence Length 25
PubChem CID Not available
Origin Animalia
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antiparasitic
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C114H198N34O33S2
Absent amino acids DEHIMPRTWY
Common amino acids K
Mass 306544
Pl 10.63
Basic residues 5
Acidic residues 0
Hydrophobic residues 9
Net charge 5
Boman Index -2574
Hydrophobicity -16.4
Aliphatic Index 86
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 125
Absorbance 280nm 5.21
Polar residues 9
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18494941
Title Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway
Doi Not available
Year 2008
Literature 2
Pubmed ID 30811391
Title Anti-leishmanial activity of Brevinin 2R and its Lauric acid conjugate type against L major: In vitro mechanism of actions and in vivo treatment potentials
Doi Not available
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 12878
This work is licensed under a Creative Commons Attribution 4.0 International License.