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P21S8Z
General Information
DRACP ID DRACP03995
Peptide Name P21S8Z
Sequence LDLTYEXLSLQⓍVVKⓍLNESY
Sequence Length 21
UniProt ID K9N5Q8
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | CC50>100 μM | CCK-8 assay | 48 h | 1 |
| Calu-3 | Lung adenocarcinoma | Carcinoma | CC50>100 μM | CCK-8 assay | 48 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine; X=L-norleucine
Chiral L
Physicochemical Information
Formula C97H149N21O29
Absent amino acids ACFGHIMPRW
Common amino acids L
Mass 254029
Pl 3.93
Basic residues 1
Acidic residues 3
Hydrophobic residues 7
Net charge -2
Boman Index -1704
Hydrophobicity 5.24
Aliphatic Index 120.48
Half Life
/
Extinction Coefficient cystines 2980
Absorbance 280nm 149
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29442512
Title Discovery of Hydrocarbon-Stapled Short alpha-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors
Doi Not available
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 15235
This work is licensed under a Creative Commons Attribution 4.0 International License.