Myotoxin II (105-117)[Y3,6W][Y5K,P9W,C11A], PEM-2 [W5K,A9W]

General Information


DRACP ID  DRACP04073

Peptide Name   Myotoxin II (105-117)[Y3,6W][Y5K,P9W,C11A], PEM-2 [W5K,A9W]

Sequence  KKWRKWLKWLAKK

Sequence Length  13

UniProt ID  P24605 

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C90H143N25O14

Absent amino acids  CDEFGHIMNPQSTVY

Common amino acids  K

Mass  201351

Pl  12.1

Basic residues  7

Acidic residues  0

Hydrophobic residues  6

Net charge  7

Boman Index  -2958

Hydrophobicity  -163.08

Aliphatic Index  67.69

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: >10 hour

Extinction Coefficient cystines  16500

Absorbance 280nm  1375

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30447380

Title  Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators

Doi Not available

Year  2019

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  16784

DRACP is developed by Dr.Zheng's team.