This work is licensed under a Creative Commons Attribution 4.0 International License.
Darobactin, Darobactin A
General Information
DRACP ID DRACP04127
Peptide Name Darobactin, Darobactin A
Sequence WNWSKSF
Sequence Length 7
UniProt ID A0A7X5H3A5
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C47H59N11O11
Absent amino acids ACDEGHILMPQRTVY
Common amino acids SW
Mass 106124
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 3
Net charge 1
Boman Index -1135
Hydrophobicity -114.29
Aliphatic Index 0
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1833.33
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34937193
Title MutaSynthetic peptide Production and Antimicrobial Characterization of Darobactin Analogs
Doi Not available
Year 2021
Literature 2
Pubmed ID 31747680
Title A new antibiotic selectively kills Gram-negative pathogens
Doi Not available
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 17389
This work is licensed under a Creative Commons Attribution 4.0 International License.