This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclo(Trp-Ala), Diketopiperazine (WA)
General Information
DRACP ID DRACP04304
Peptide Name Cyclo(Trp-Ala), Diketopiperazine (WA)
Sequence WA
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C14H17N3O3
Absent amino acids CDEFGHIKLMNPQRSTVY
Common amino acids AW
Mass 29333
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 414
Hydrophobicity 45
Aliphatic Index 50
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 5500
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 35200615
Title Anti-Quorum-Sensing Activity of Tryptophan-Containing Cyclic Dipeptides
Doi Not available
Year 2022
Literature 2
Pubmed ID 32806659
Title C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities
Doi Not available
Year 2020
Literature 3
Pubmed ID 22617493
Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Doi Not available
Year 2012
Literature 4
Pubmed ID 23079524
Title Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmus luteoalbus SCSIO F457
Doi Not available
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 18855
This work is licensed under a Creative Commons Attribution 4.0 International License.