This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclo(Trp-Trp), Diketopiperazine (WW)
General Information
DRACP ID DRACP04307
Peptide Name Cyclo(Trp-Trp), Diketopiperazine (WW)
Sequence WW
Sequence Length 2
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C22H22N4O3
Absent amino acids ACDEFGHIKLMNPQRSTVY
Common amino acids W
Mass 40846
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 2
Net charge 0
Boman Index 466
Hydrophobicity -90
Aliphatic Index 0
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 11000
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 32806659
Title C7-Prenylation of Tryptophan-Containing Cyclic Dipeptides by 7-Dimethylallyl Tryptophan Synthase Significantly Increases the Anticancer and Antimicrobial Activities
Doi Not available
Year 2020
Literature 2
Pubmed ID 21193822
Title Identification of Streptomyces sp KH29, which produces an antibiotic substance processing an inhibitory activity against multidrug-resistant Acinetobacter baumannii
Doi Not available
Year 2010
Literature 3
Pubmed ID 22617493
Title Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides
Doi Not available
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 18861
This work is licensed under a Creative Commons Attribution 4.0 International License.