This work is licensed under a Creative Commons Attribution 4.0 International License.
NYBSP-C
General Information
DRACP ID DRACP04381
Peptide Name NYBSP-C
Sequence TIEEQAKTFLDKFNHEAEDLFYQSSLASWN
Sequence Length 30
UniProt ID Q9BYF1
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT1080/ACE2 | Fibrosarcoma | Sarcoma | CC50>27.7 μM | MTS assay | 24 h | 1 |
| A549/ACE2 | Lung adenocarcinoma | Carcinoma | CC50>27.7 μM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity 19
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C161H233N39O53
Absent amino acids CGMPRV
Common amino acids E
Mass 408030
Pl 4.1
Basic residues 3
Acidic residues 6
Hydrophobic residues 11
Net charge -3
Boman Index -6390
Hydrophobicity -74.33
Aliphatic Index 62
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 6990
Absorbance 280nm 241.03
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33310780
Title Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 19261
This work is licensed under a Creative Commons Attribution 4.0 International License.