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NYBSP-2
General Information
DRACP ID DRACP04383
Peptide Name NYBSP-2
Sequence TIEEQⓍKTFLDKⓍNHEAEDLⓍYQSSLAⓍWN
Sequence Length 30
UniProt ID Q9BYF1
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HT1080/ACE2 | Fibrosarcoma | Sarcoma | CC50>26.8 μM | MTS assay | 24 h | 1 |
| A549/ACE2 | Lung adenocarcinoma | Carcinoma | CC50>26.8 μM | MTS assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity 61
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (13), Ⓧ(21) and Ⓧ (28) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(6/21)=(R)-2-(7-octenyl) alanine; Ⓧ(13/28)=S-2-(4-pentenyl) alanine
Chiral L
Physicochemical Information
Formula C137H197N35O44
Absent amino acids CGMPRV
Common amino acids E
Mass 355573
Pl 4.1
Basic residues 3
Acidic residues 6
Hydrophobic residues 8
Net charge -3
Boman Index -6827
Hydrophobicity -96.33
Aliphatic Index 58.67
Half Life
/
Extinction Coefficient cystines 6990
Absorbance 280nm 241.03
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33310780
Title Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 19268
This work is licensed under a Creative Commons Attribution 4.0 International License.