This work is licensed under a Creative Commons Attribution 4.0 International License.
Pleurocidin [K7,8,14,18R]
General Information
DRACP ID DRACP04576
Peptide Name Pleurocidin [K7,8,14,18R]
Sequence GWGSFFRRAAHVGRHVGRAALTHYL
Sequence Length 25
UniProt ID P81941
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C129H192N44O29
Absent amino acids CDEIKMNPQ
Common amino acids AGR
Mass 325149
Pl 12.5
Basic residues 7
Acidic residues 0
Hydrophobic residues 11
Net charge 7
Boman Index -4256
Hydrophobicity -16.4
Aliphatic Index 70.4
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 291.25
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33247193
Title A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy
Doi Not available
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID 20612
This work is licensed under a Creative Commons Attribution 4.0 International License.