This work is licensed under a Creative Commons Attribution 4.0 International License.
Pentastatin-1
General Information
DRACP ID DRACP04928
Peptide Name Pentastatin-1
Sequence LRRFSTMPFMFCNINNVCNF
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Homo sapiens (α5 CIV)
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target αvβ3, αvβ1
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic
Disulfide/Other Bond Native peptide
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C109H164N30O27S4
Absent amino acids ADEGHKQWY
Common amino acids FN
Mass 279399
Pl 8.83
Basic residues 2
Acidic residues 0
Hydrophobic residues 7
Net charge 2
Boman Index -2931
Hydrophobicity 32
Aliphatic Index 53.5
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 6.58
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 18780781
Title A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells
Year 2008
Literature 2
Pubmed ID 21470139
Title Anti-angiogenic peptides for cancer therapeutics
Doi 10.2174/138920111796117300
Year 2011
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.