This work is licensed under a Creative Commons Attribution 4.0 International License.
i7-01s-18
General Information
DRACP ID DRACP05818
Peptide Name i7-01s-18
Sequence MLIDⓍLIDVVKⓍRVV
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce necrosis
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK 293T: Negligible cytotoxicity
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(5)=(R)-2-Amino-2-methyl-9-decenoic acid; Ⓧ(12)=(S)-2-Amino-2-methyl-6-heptenoic acid
Chiral L
Physicochemical Information
Formula C69H121N17O16S
Absent amino acids ACEFGHNPQSTWY
Common amino acids V
Mass 172680
Pl 6.45
Basic residues 2
Acidic residues 2
Hydrophobic residues 8
Net charge 0
Boman Index 28
Hydrophobicity 132.67
Aliphatic Index 181.33
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2022237853A1
Patent Title Beclin1-Targeted Stapled Peptide and Pharmaceutical Composition
Other Iinformation Not available
Other Published ID CN113402588A CN113402588B
This work is licensed under a Creative Commons Attribution 4.0 International License.