This work is licensed under a Creative Commons Attribution 4.0 International License.
i7-01s-24
General Information
DRACP ID DRACP05824
Peptide Name i7-01s-24
Sequence YLIQⓍLIYVEKⓍRQI
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce necrosis
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK 293T: Negligible cytotoxicity
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(5)=(R)-2-Amino-2-methyl-9-decenoic acid; Ⓧ(12)=(S)-2-Amino-2-methyl-6-heptenoic acid
Chiral L
Physicochemical Information
Formula C80H127N19O18
Absent amino acids ACDFGHMNPSTW
Common amino acids I
Mass 189291
Pl 9.15
Basic residues 2
Acidic residues 1
Hydrophobic residues 6
Net charge 1
Boman Index -1000
Hydrophobicity 25.33
Aliphatic Index 149.33
Half Life
/
Extinction Coefficient cystines 2980
Absorbance 280nm 212.86
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2022237853A1
Patent Title Beclin1-Targeted Stapled Peptide and Pharmaceutical Composition
Other Iinformation Not available
Other Published ID CN113402588A CN113402588B
This work is licensed under a Creative Commons Attribution 4.0 International License.