i7-01s-26

General Information


DRACP ID  DRACP05826

Peptide Name   i7-01s-26

Sequence  QLIQⓍLFYVLKⓍIKV

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Induce necrosis



Activity Information


Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK 293T: Negligible cytotoxicity

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Ⓧ(5)=(R)-2-Amino-2-methyl-9-decenoic acid; Ⓧ(12)=(S)-2-Amino-2-methyl-6-heptenoic acid

Chiral  L



Physicochemical Information


Formula  C80H129N17O15

Absent amino acids  ACDEGHMNPRSTW

Common amino acids  L

Mass  181892

Pl  10.25

Basic residues  2

Acidic residues  0

Hydrophobic residues  8

Net charge  2

Boman Index  1334

Hydrophobicity  103.33

Aliphatic Index  168.67

Half Life 
  /

Extinction Coefficient cystines  1490

Absorbance 280nm  106.43

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID Not available

Title  Not available

Doi Not available

Year  Not available

Patent

Patent ID WO2022237853A1

Patent Title  Beclin1-Targeted Stapled Peptide and Pharmaceutical Composition

Other Iinformation  Not available

Other Published ID  CN113402588A  CN113402588B 




DRACP is developed by Dr.Zheng's team.