This work is licensed under a Creative Commons Attribution 4.0 International License.
i7-01s-34
General Information
DRACP ID DRACP05834
Peptide Name i7-01s-34
Sequence RFIQⓍLEVVIKⓍRSV
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Induce necrosis
Activity Information
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK 293T: Negligible cytotoxicity
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(5) and Ⓧ (12) are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ(5)=(R)-2-Amino-2-methyl-9-decenoic acid; Ⓧ(12)=(S)-2-Amino-2-methyl-6-heptenoic acid
Chiral L
Physicochemical Information
Formula C73H123N21O16
Absent amino acids ACDGHMNPTWY
Common amino acids V
Mass 180080
Pl 11.48
Basic residues 3
Acidic residues 1
Hydrophobic residues 7
Net charge 2
Boman Index -2128
Hydrophobicity 50
Aliphatic Index 136
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID Not available
Title Not available
Doi Not available
Year Not available
Patent
Patent ID WO2022237853A1
Patent Title Beclin1-Targeted Stapled Peptide and Pharmaceutical Composition
Other Iinformation Not available
Other Published ID CN113402588A CN113402588B
This work is licensed under a Creative Commons Attribution 4.0 International License.