Peptide Libraray

Alyteserin-2a-Sp3

General Information

DRACP ID DRACP05878

Peptide Name Alyteserin-2a-Sp3

Sequence ILGKLLSTAⓍGLLⓍNL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=0.99±0.21 μM	CCK-8 assay	72 h	1
U87	Glioblastoma	Blastoma	IC50=3.9±0.010 μM	CCK-8 assay	72 h	1
A549	Lung adenocarcinoma	Carcinoma	IC50=2.8±0.90 μM	CCK-8 assay	72 h	1
MDA-MB-231	Breast adenocarcinoma	Carcinoma	IC50=0.86μM	CCK-8 assay	72h	Patent

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity 80.1

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ are cross-linked by hydrocarbon stapling

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine (S5)

Chiral L

Physicochemical Information

Formula C66H116N16O16

Absent amino acids CDEFHMPQRVWY

Common amino acids L

Mass 165750

Pl 9.7

Basic residues 1

Acidic residues 0

Hydrophobic residues 8

Net charge 1

Boman Index 1997

Hydrophobicity 121.25

Aliphatic Index 176.88

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34989078

Title Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents

Doi 10.1002/psc.3401

Year 2022

Patent

Patent ID CN115160406A

Patent Title Preparation method and application of novel anti-tumor cyclic peptide active molecules

Other Iinformation Not available

Other Published ID Not available