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Alyteserin-2a-Sp4
General Information
DRACP ID DRACP05879
Peptide Name Alyteserin-2a-Sp4
Sequence ILGKLLⓍTAAGLLⓍNL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=8.5±1.4 μM | CCK-8 assay | 72 h | 1 |
| U87 | Glioblastoma | Blastoma | IC50=10.1±1.6 μM | CCK-8 assay | 72 h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | IC50=11.6±2.2 μM | CCK-8 assay | 72 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=9.2μM | CCK-8 assay | 72h | Patent |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity 51
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ(7) and Ⓧ (14) are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification Ⓧ(7)=(R)-2-(7-octenyl)alanine; Ⓧ(14)=(S)-2-(4-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C66H116N16O15
Absent amino acids CDEFHMPQRSVWY
Common amino acids L
Mass 164151
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 9
Net charge 1
Boman Index 2518
Hydrophobicity 137.5
Aliphatic Index 183.13
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 34989078
Title Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents
Doi 10.1002/psc.3401
Year 2022
Patent
Patent ID CN115160406A
Patent Title Preparation method and application of novel anti-tumor cyclic peptide active molecules
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.