Peptide Libraray

Alyteserin-2a-Sp5

General Information

DRACP ID DRACP05880

Peptide Name Alyteserin-2a-Sp5

Sequence ILⓍKLLSTAⓍGLLSNL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=5.2±0.91 μM	CCK-8 assay	72 h	1
U87	Glioblastoma	Blastoma	IC50=9.5±2.0 μM	CCK-8 assay	72 h	1
A549	Lung adenocarcinoma	Carcinoma	IC50=8.4±1.8 μM	CCK-8 assay	72 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity 67.7

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(3) and Ⓧ (10) are cross-linked by hydrocarbon stapling

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification Ⓧ(3)=(R)-2-(7-octenyl)alanine; Ⓧ(10)=(S)-2-(4-pentenyl)alanine

Chiral L

Physicochemical Information

Formula C67H118N16O17

Absent amino acids CDEFHMPQRVWY

Common amino acids L

Mass 168752

Pl 9.7

Basic residues 1

Acidic residues 0

Hydrophobic residues 8

Net charge 1

Boman Index 1563

Hydrophobicity 118.75

Aliphatic Index 176.88

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 34989078

Title Hydrocarbon stapling modification of peptide alyteserin-2a: Discovery of novel stapled peptide antitumor agents

Doi 10.1002/psc.3401

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available