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B1-L-4
General Information
DRACP ID DRACP05884
Peptide Name B1-L-4
Sequence VKRFKKFFⓍKLKⓍLV
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=13.41±1.92 μM | CCK-8 assay | 48 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=15.20±1.02 μM | CCK-8 assay | 48 h | 1 |
| U87 | Glioblastoma | Blastoma | IC50=17.91±3.23 μM | CCK-8 assay | 48 h | 1 |
Hemolytic Activity HC50>80 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity 35
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ are cross-linked by hydrocarbon stapling
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4-pentenyl) alanine amino acid
Chiral L
Physicochemical Information
Formula C85H137N21O12
Absent amino acids ACDEGHIMNPQSTWY
Common amino acids K
Mass 189504
Pl 12.05
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -1581
Hydrophobicity 2.67
Aliphatic Index 90.67
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 35464194
Title Design, Synthesis, and Antitumor Activity Study of All-Hydrocarbon-Stapled B1-Leu Peptides
Year 2022
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.