B1-L-4

General Information


DRACP ID  DRACP05884

Peptide Name   B1-L-4

Sequence  VKRFKKFFⓍKLKⓍLV

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
Huh-7 Adult hepatocellular carcinoma; Adult hepatocellular carcinoma Carcinoma IC50=13.41±1.92 μM CCK-8 assay 48 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=15.20±1.02 μM CCK-8 assay 48 h 1
U87 Glioblastoma Blastoma IC50=17.91±3.23 μM CCK-8 assay 48 h 1

Hemolytic Activity  HC50>80 μM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  35

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ are cross-linked by hydrocarbon stapling

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  Ⓧ=(S)-2-(4-pentenyl) alanine amino acid

Chiral  L



Physicochemical Information


Formula  C85H137N21O12

Absent amino acids  ACDEGHIMNPQSTWY

Common amino acids  K

Mass  189504

Pl  12.05

Basic residues  6

Acidic residues  0

Hydrophobic residues  7

Net charge  6

Boman Index  -1581

Hydrophobicity  2.67

Aliphatic Index  90.67

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 35464194

Title  Design, Synthesis, and Antitumor Activity Study of All-Hydrocarbon-Stapled B1-Leu Peptides

Doi 10.3389/fchem.2022.840131

Year  2022

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.