Peptide Libraray

B1-L-7

General Information

DRACP ID DRACP05887

Peptide Name B1-L-7

Sequence VKRFKⓍFFRKLKⓍLV

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
Huh-7	Adult hepatocellular carcinoma; Adult hepatocellular carcinoma	Carcinoma	IC50=7.49±1.2 μM	CCK-8 assay	48 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=13.36±1.22 μM	CCK-8 assay	48 h	1
U87	Glioblastoma	Blastoma	IC50=12.70±1.63 μM	CCK-8 assay	48 h	1

Hemolytic Activity HC50>80 μM

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity 31.6

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(6) and Ⓧ (13) are cross-linked by hydrocarbon stapling

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification Ⓧ(6)=(R)-2-(7-octenyl) alanine amino acid; Ⓧ(13)=(S)-2-(4-pentenyl) alanine amino acid

Chiral L

Physicochemical Information

Formula C85H137N23O12

Absent amino acids ACDEGHIMNPQSTWY

Common amino acids K

Mass 192305

Pl 12.56

Basic residues 6

Acidic residues 0

Hydrophobic residues 7

Net charge 6

Boman Index -2518

Hydrophobicity -1.33

Aliphatic Index 90.67

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 35464194

Title Design, Synthesis, and Antitumor Activity Study of All-Hydrocarbon-Stapled B1-Leu Peptides

Doi 10.3389/fchem.2022.840131

Year 2022

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available