A4K14-citropin1.1-Sp2

General Information


DRACP ID  DRACP05889

Peptide Name   A4K14-citropin1.1-Sp2

Sequence  GLFAⓍIKKⓍASVIKGL

Sequence Length  16

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Cancer targeted peptides Stapled Peptides Membrane-targeted



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
C4-2B Prostate carcinoma Carcinoma IC50=10.14 μM CCK-8 assay 96 h 1
A549 Lung adenocarcinoma Carcinoma IC50=12.55 μM CCK-8 assay 96 h 1
U87 Glioblastoma Blastoma IC50=14.76 μM CCK-8 assay 96 h 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=12.65 μM CCK-8 assay 96 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  66.1

Linear/Cyclic  Cyclic (Stapled)

Disulfide/Other Bond  Stapled: Ⓧ are cross-linked by hydrocarbon stapling

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  Ⓧ=(S)-2-(4-pentenyl)alanine

Chiral  L



Physicochemical Information


Formula  C69H117N17O14

Absent amino acids  CDEHMNPQRTWY

Common amino acids  K

Mass  167654

Pl  11.1

Basic residues  3

Acidic residues  0

Hydrophobic residues  8

Net charge  3

Boman Index  1215

Hydrophobicity  86.88

Aliphatic Index  128.13

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 33363118

Title  Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides

Doi 10.3389/fchem.2020.616147

Year  2020

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.