A4K14-citropin1.1-Sp5
General Information
DRACP ID DRACP05892
Peptide Name A4K14-citropin1.1-Sp5
Sequence GLFAVIKKVAⓍVIKⓍL
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Stapled Peptides Membrane-targeted
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
C4-2B | Prostate carcinoma | Carcinoma | IC50=11.90 μM | CCK-8 assay | 96 h | 1 |
A549 | Lung adenocarcinoma | Carcinoma | IC50=9.899 μM | CCK-8 assay | 96 h | 1 |
U87 | Glioblastoma | Blastoma | IC50=8.229 μM | CCK-8 assay | 96 h | 1 |
MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=12.42 μM | CCK-8 assay | 96 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity 49.4
Linear/Cyclic Cyclic (Stapled)
Disulfide/Other Bond Stapled: Ⓧ are cross-linked by hydrocarbon stapling
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification Ⓧ=(S)-2-(4-pentenyl)alanine
Chiral L
Physicochemical Information
Formula C74H127N17O13
Absent amino acids CDEHMNPQRSTWY
Common amino acids KV
Mass 173068
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index 2269
Hydrophobicity 146.88
Aliphatic Index 164.38
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 33363118
Title Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available