Peptide Libraray

A4K14-citropin1.1-Sp6

General Information

DRACP ID DRACP05893

Peptide Name A4K14-citropin1.1-Sp6

Sequence GⓍFAVIKKⓍASVIKGL

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Cancer targeted peptides Stapled Peptides Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
C4-2B	Prostate carcinoma	Carcinoma	IC50=35.84 μM	CCK-8 assay	96 h	1
A549	Lung adenocarcinoma	Carcinoma	IC50=30.19 μM	CCK-8 assay	96 h	1
U87	Glioblastoma	Blastoma	IC50=34.49 μM	CCK-8 assay	96 h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=23.78 μM	CCK-8 assay	96 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity 34.9

Linear/Cyclic Cyclic (Stapled)

Disulfide/Other Bond Stapled: Ⓧ(2) and Ⓧ (9) are cross-linked by hydrocarbon stapling

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification Ⓧ(2)=(S)-2-(4-pentenyl)alanine; Ⓧ(9)=(R)-2-(7-octenyl)alanine

Chiral L

Physicochemical Information

Formula C68H115N17O14

Absent amino acids CDEHMNPQRTWY

Common amino acids K

Mass 166251

Pl 11.1

Basic residues 3

Acidic residues 0

Hydrophobic residues 8

Net charge 3

Boman Index 1127

Hydrophobicity 89.38

Aliphatic Index 121.88

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 33363118

Title Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides

Doi 10.3389/fchem.2020.616147

Year 2020

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available