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RT53
General Information
DRACP ID DRACP05895
Peptide Name RT53
Sequence RQIKIWFQNRRMKWKKAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKT
Sequence Length 53
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cancer targeted peptides Induce necrosis
Activity Information
Hemolytic Activity Mice red blood cells: 8% Hemolysis=20 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C306H503N93O69S
Absent amino acids CHPS
Common amino acids K
Mass 754872
Pl 12.21
Basic residues 16
Acidic residues 2
Hydrophobic residues 21
Net charge 14
Boman Index -13606
Hydrophobicity -77.74
Aliphatic Index 93.96
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 13980
Absorbance 280nm 268.85
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30080874
Title The anticancer peptide RT53 induces immunogenic cell death
Doi 10.1371/journal.pone.0201220
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.